Inhibitory Effects of Swietenia Mahagoni Seeds Extract on Α-Glucosidase and Α-amylase
محل انتشار: ماهنامه بین المللی مهندسی، دوره: 31، شماره: 8
سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 337
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شناسه ملی سند علمی:
JR_IJE-31-8_020
تاریخ نمایه سازی: 10 آذر 1398
چکیده مقاله:
This study analyzed the inhibition activity of Swietenia mahagoni seeds extract on α-glucosidase and α-amylase enzymes inhibition assays. Swietenia mahagoni seeds were extracted by using Supercritical Carbon Dioxide (SC-CO2) extraction at pressures of 20- 30 MPa and temperatures of 40- 60°C. The oil yields obtained were analyzed with α- glucosidase and α- amylase enzymes inhibition assays. All data obtained were expressed as mean ± standard deviation for triplicate experiments. One way analysis was used for statistical significance by using Statistica software version 7.0 (StartSoft, EUA) and IC50 (extract concentration causing 50% enzyme inhibitory) was determined by using GraphPad Prism 6.0 software. Swietenia mahagoni seeds extract have a strong inhibition of α-glucosidase enzyme activity (98.4% ± 0.2) but a moderate inhibition of α- amylase enzyme activity (34.9% ± 1.2). These findings implied that Swietenia mahagoni seeds extract could be an effective natural antidiabetic agent.
کلیدواژه ها:
Swietenia mahagoni seed ، α ، glucosidase enzyme ، amylase enzyme ، Supercritical Carbon Dioxide (SC ، CO2) extraction
نویسندگان
Nor Asyiqin Bakeri
Department of Bioprocess and Polymer Engineering, Universiti Teknologi Malaysia
Mohd Amzar Mohamed Zahari
Department of Bioprocess and Polymer Engineering, Universiti Teknologi Malaysia
Firdaus Kamarulzaman
Natural Product Division, Forest Research Institute Malaysia (FRIM)
Nohaniza Yusof
Advanced Membrane Technology Research Centre (AMT, Universiti Teknologi Malaysia