Thyroid Dysfunction and Their Risk Factors among Pregnant Women: A Report from an Adequate Iodine Region
- سال انتشار: 1398
- محل انتشار: پنجمین همایش بین المللی و هفتمین همایش سراسری تازه های غدد و متابولیسم
- کد COI اختصاصی: ICEMU05_081
- زبان مقاله: انگلیسی
- تعداد مشاهده: 514
نویسندگان
Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Biostatistics & Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Biostatistics & Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده
Introduction: Thyroid dysfunction, a common complication of pregnancy, is associated with adverse prenatal consequences. This study aimed to determine the prevalence of thyroid dysfunction and thyroid peroxidase antibody, and measure iodine level during the first trimester of pregnancy among Iranian women.Materials and Methods: In the first phase of a population-based cohort study, 418 pregnant women in their first trimester of pregnancy, and 438 non-pregnant women, were enrolled. Serum concentrations of TSH, FT4, FT3, TPO-Ab and urinary iodine concentrations, of all participants were measured. Results: During the first trimester of gestation, the prevalence of overt and subclinical hypothyroidism was 4.32%, 17.03%, respectively. The prevalence of overt and subclinical hyperthyroidism was 0.23%, 1.2 %, respectively. Among non–pregnant women, 2.1% had overt and 4.6% had subclinical hypothyroidism. The prevalence of subclinical and overt hyperthyroidism in non-pregnant women was 0.5% and 0.7%, respectively. Overall, 17.9 % of pregnant and 21.9% of non-pregnant women were positive for TPO-Ab. Positive TPO-Ab was a risk factor for hypothyroidism, in both pregnant and non-pregnant women (RR=2.325, P=0.003 and RR=6.359, P=0.001, respectively). The median (Interquartile range (IQR)) of urinary iodine concentration (UIC) in pregnant women was 154 μg/l (108.0-216.2 μg/l) and 169.0 μg/L (109.7 – 250.0 μg/l), respectively.Conclusions: We report high prevalence of hypothyroidism and positive TPO-Ab in pregnant and childbearing-age women, despite adequate iodine intake. There was a strong association between hypothyroidism and positive TPO-Ab. The role of high prevalence of autoimmunity should be investigated in future studies.کلیدواژه ها
مقالات مرتبط جدید
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.