The accuracy of FEF25-75/FVC for primary classification of pulmonary function test

  • سال انتشار: 1397
  • محل انتشار: کنگره بین المللی بیماری های راه های هوایی و بینابینی ریه
  • کد COI اختصاصی: AILDMED01_026
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 523
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نویسندگان

Majid Mirsadraei

Department of Internal Medicine, Medical School of Islamic Azad University- Mashhad Branch, Mashhad, Iran.

Davoud Attaran

Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

چکیده

Introduction: FEF25-75/FVC as a spirometry parameter has been successful in early diagnosis of COPD and the methacholine challenge test. This study was performed todetermine the accuracy of FEF25-75/FVC for classification of spirometry of lung disease. Materials and Methods: Eighty subjects with clinical diagnosis of COPD and idiopathic pulmonary fibrosis (IPF) were entered into this case control study. Forty normal volunteers in the control groups with a PC20 more than 8 mg/dl were also included in this study. Spirometry, lung volumes and DLCO were measured for all subjects by the body plethysmograph. Final diagnosis of COPD and IPF were confirmed according topatient s history, the pulmonary function test, computed tomography of the lung and histopathology (in IPF subjects). The FEF25-75/FVC ratio was determined in each group and test accuracy was compared by lung volumes and DLCO as the gold standard. Results: FEF25-75/FVC was able to partition the subjects into four categories and itsagreement with the clinical diagnosis (kappa= 0.486) was more than FEV1/FVC and RV. Assessing accuracy showed that FEF25-75/FVC had the highest likelihood ratio followed by FEV1/FVC. Mid expiratory flow parameters including FEF25-75 and FEF25-75/FVC showed the highest sensitivity, positive predicted value, negative predicted value, and efficiency. Conclusion: FEF25-75/FVC is helpful in diagnosing difficult cases such as mixed type spirometry or spirometry results that are not matched with clinical findings without need of lung volume measurement.

کلیدواژه ها

COPD, Dysanapsis, FEF25-75/FVC, Idiopathic pulmonary fibrosis, MMEF/FVC, Spirometry.

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