Fabrication of polymeric wound dressing using by bio ceramic nanoparticles for rapid healing of trauma wounds by freeze-dryingmethod

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 491

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شناسه ملی سند علمی:

NCNNN03_002

تاریخ نمایه سازی: 5 آذر 1398

چکیده مقاله:

Skin injuries mainly include chronic wounds, burns, and cuts. An injury in medical science isdamage that causes the skin to be scratched, torn, cut, pierced or shattered, or due to a trauma, eventhough the skin remains healthy but there may be red or bruising effects. In short, the separation ofthe intercellular junction is called part of the skin or flesh wound. Injuries are divided into two typesof closed and open injuries; cuts or ruptures of the skin, including open injuries and bruises on theskin are common closed injuries. Severe injuries to the soft tissue of the skin are known as traumawounds. Abrasions, cuts and tears are trauma wounds, and they can become infected if leftuntreated. Therefore, today the fabrication of wound dressings for wound healing has increaseddramatically. Traditional wound dressing delays the wound healing process by creating a dryenvironment, while the wound bed requires an open and healthy wound healing environment,leading to traditional wound dressing replacing to the new generation of the wound dressing. In thisstudy, bio nanocomposite scaffolds were prepared by nanocrystalline hydroxyapatite powder (HA)and titanium oxide (TiO2) (prepared by mechanical grinding method) by freeze-drying method withdifferent values of 0, 5, 10 and 15 wt% of TiO2. Then mechanical tests were performed toinvestigate the tensile strength of the porous samples. The mechanical properties of the scaffoldswere also evaluated using a tensile test device to obtain the stress-strain diagram. The matrix of thiscomposite is biocompatible polycaprolactone (PCL). This polymer is semi-crystalline, so fordissolution of this polymer, dimethylformamid (DMF) solvent was used, which is common solvent in chemistry, Finally, scaffolds implant on the animal s body as wound dressings to treat traumawounds.

نویسندگان

Ashkan Farazin

Department of Solid Mechanics, PhD student of Mechanical Engineering University of Kashan, Kashan, Iran

Farshid Aghadavoudi

۲Department of Mechanical engineering, Khomeinishahr Branch, Islamic Azad University, Khomeinishahr /Isfahan, Iran