Measurement of anti-HBs antibody titers among Health Care Personnel of Mofid Children s Hospital

Background and Objectives: Vaccination against hepatitis B virus is the primary mode of prevention in healthcare personnel (HCP). Standard adult vaccination schedule is 3 doses of recombinant vaccine administered intramuscularly. Vaccine-induced anti-HBs levels ≥10 mIU/mL are considered to represent seroprotection. This study aimed to determine current immune status and main risk factors for incomplete immunization and or seroprotection in HCP of Mofid Children s hospital . Materials and Methods: Sera of freshly collected blood samples from HCP of Mofid Children s hospital were used for quantitative measurement of AntiHBs titers using enzyme linked immunoassay. Demographic data of the participants were provided using a predesigned questionnaire. Statistical analyses were done using SPSS software . Results: Out of 180 participants in this study, 75.7% showed antibody titers ≥10 mIU/ml. This titer was observed most commonly among females (80.2% vs 54.8%), and younger personnel (80.6% vs 69% among those with ≤30 years old). The least titers were observed among attendants and physicians, while optimum titers detected among the nurses. Antibody titers <10 mIU/ml showed a correlation with obesity, where 46.1% of HCP with BMI > 30 presented lower antiHBs titers, compared with 24.8% among those with normal BMI. Impact of incomplete vaccination on titers of antiHBs was also confirmed in our study, where insufficient antibody titers were most commonly measured among the HCP with 1 or 2 doses of vaccination history . Conclusion: Results of this study showed insufficient antiHBs titers among HCP of Mofid Children s Hospital. Further studies are needed to determine non-responders, based on their last vaccination history, underlying diseases, medication, and the immune status.