Association Between Intracellular Adhesion Molecule Polymorphism (ICAM-I) and Breast Cancer Incidence in Urmia Women

Breast cancer is one of the most prominent cancers in women worldwide. The ICAM-I molecule, also known as CD54, is a cell surface glycoprotein that is expressed on the cells within the vein and the immune system. Mutations in this gene disrupt apoptosis metabolism. The purpose of this study was to investigate the relationship between intracellular adhesion molecule polymorphism (ICAM-I) and the incidence of breast cancer in women.Materials and Method: Our statistical population includes 5 breast cancer patients and 50 healthy women as control group. ICAM-I biopsy specimens were prepared and then stained with indirect immunofluorescent and hematoxylin eosin and then the results were normalized. SPSS v.24 and T-test were used for data analysis.Results: The highest mean decrease of expression of these molecules was observed in patients of 5 to 5 years old age group. Comparison of ICAM-I correlation coefficients in the slides of patients with control group was 5% and 5%, respectively. There was a significant association with disease incidence (P = 0.04) (CL = 1.07-3.18-OR = 95%). There was a significant correlation with disease incidence (P = 0.03) (CL = 1.55-3.69-OR = 95%). Also, a positive correlation was observed between the disease and the decrease with a significant difference.Conclusions: Based on the results of ICAM-I, there is a significant relationship between the incidence of breast cancer and which can be used as one of the pre-disease factors