Masoud Hashemi-Arabi - Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Sajad Sahab Negah - Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Ali Gorji - Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Epilepsy is a multifactorial and heterogeneous disorder. Molecular and biochemical events involved in its occurrence which is not fullyunderstood and require more research. Oxidative stress is developing as a mechanism that may play a key role in the etiology of seizure induced neuronal death. In a specific pathologic process like oxidative stress generation the free radical called reactive oxygen species(ROS) result in oxidative damage to cellular proteins, lipids, and DNA. Episodes of seizures can be prevented by reducing causative or precipitating factors. Use of antioxidants can be effective in this way. Conclusion: We suggested that tert-Butylhydroquinone (tBHQ) asa phenolic antioxidant improved electrophysiological parameters and behavioral changes in PTZ induction seizure in rat.