Medical Treatment of Non-Steroidal Anti- Inflammatory Drugs on Alzheimer’s Disease: Systematic Review and Meta-Analysis
- سال انتشار: 1398
- محل انتشار: سومین همایش بین المللی التهاب سیستم عصبی و سومین فستیوال دانشجویی علوم اعصاب
- کد COI اختصاصی: NIMED03_308
- زبان مقاله: انگلیسی
- تعداد مشاهده: 374
نویسندگان
Student Research Committee, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Student Research Committee, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Student Research Committee, Mashhad Branch, Islamic Azad University, Mashhad, Iran
چکیده
Alzheimer’s disease is one of the neurodegenerative diseases which affected 50 million people in the world. Laboratory findings indicates thatnonsteroidal anti-inflammatory drugs (NSAIDs) may improve the Alzheimer’s disease. The aim of this study is to systematically reviewed available researches about the relation of NSAIDs and Alzheimer’s disease. A systematic search was done using Embase, PubMed, Google Scholar and Science Direct for publications from 2013 to 2018. All retrospective, or prospective observational studies andcross-sectional studies, of Alzheimer’s disease in relation to NSAID exposure were included. Data extraction was done using a standardized data extraction tool in Microsoft Office Excel 2013. All the analyses were done using Stata V.15.0. . Of 28 articles, 9 ones had the qualitative criteria for inclusion in our study. According to the 2 crosssectional and 3 case-control studies, the combined risk evaluate for progress of Alzheimer’s disease was 0.36 (95% CI = 0.34–0.58) for exposure with NSAID. In the observational investigations, the approximation was 0.68(95% CI = 0.59–0.79) for the 4 studies about the relation between lifetime using NSAID. Conclusion: According to the analysis, NSAIDs had a role in the protection against the progress of Alzheimer’s disease and it may decrease the risk of Alzheimer’s disease.کلیدواژه ها
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