Medical Treatment of Non-Steroidal Anti- Inflammatory Drugs on Alzheimer’s Disease: Systematic Review and Meta-Analysis

Alzheimer’s disease is one of the neurodegenerative diseases which affected 50 million people in the world. Laboratory findings indicates thatnonsteroidal anti-inflammatory drugs (NSAIDs) may improve the Alzheimer’s disease. The aim of this study is to systematically reviewed available researches about the relation of NSAIDs and Alzheimer’s disease. A systematic search was done using Embase, PubMed, Google Scholar and Science Direct for publications from 2013 to 2018. All retrospective, or prospective observational studies andcross-sectional studies, of Alzheimer’s disease in relation to NSAID exposure were included. Data extraction was done using a standardized data extraction tool in Microsoft Office Excel 2013. All the analyses were done using Stata V.15.0. . Of 28 articles, 9 ones had the qualitative criteria for inclusion in our study. According to the 2 crosssectional and 3 case-control studies, the combined risk evaluate for progress of Alzheimer’s disease was 0.36 (95% CI = 0.34–0.58) for exposure with NSAID. In the observational investigations, the approximation was 0.68(95% CI = 0.59–0.79) for the 4 studies about the relation between lifetime using NSAID. Conclusion: According to the analysis, NSAIDs had a role in the protection against the progress of Alzheimer’s disease and it may decrease the risk of Alzheimer’s disease.