Mohammad Reza Khakzad - Innovative Medical Research Center, Department of Immunology, Faculty of Medicine, Islamic Azad University, Mashhad, Iran
Elahe Karazhian - Innovative Medical Research Center, Department of Immunology, Islamic Azad University, Mashhad, Iran

The prevalence of autism and allergy has risen dramatically in the last two decades causing a major public health issues in the developed countries. One of the main issues discussed in this research is that, why despite a few numbers of foods are involved in food allergy, it s prevalence is rising worldwide Neuroimmune system has an essential role in neuroinflammation and behavioral changes in autism.Today, we know that food allergies affect on neural responses. Mast cells are abundant in the deep parts of the central nervous system. Mast cells have numerous granules that during degranulation, release histamine and other mediators which can stimulate the centralnervous system. Histamine H3 receptors predominantly exist in the brain. Mast cell interactions with the nerve cells result in neuroinflammation and neurodegeneration which can disrupt the blood-brain barrier (BBB). In addition, food intolerance, food chemical sensitivities and food poisoning are non-immunological responses to food that have similar symptoms and signs of foodallergy. Furthermore, some of the peptide fragments such as gluten and casein can mimic some chemicals in the brain called endorphins. The common clinical symptoms of patients with food allergies, other behavioral symptoms including sleep, social interaction and, learning disorders, irritability, stress, anxiety, and depression may be observed in the children suffering from Child food allergy. Conclusion: The key question is that do autistic children with food allergy, talk to their parents or teachers about their problems Even in normal children with food allergies, many of these symptoms are hidden. This research focuses on the relationship between autism and child food allergies.