Investigation of Microrna-326 Changes in Multiple Sclerosis Patients: Systematic Review

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 268

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شناسه ملی سند علمی:

NIMED03_256

تاریخ نمایه سازی: 7 آبان 1398

چکیده مقاله:

Multiple Sclerosis (MS) is an inflammatory autoimmune disease with immune related pathogenesis process that caused myelin degeneration of the central nervous system (CNS). microRNAs(miRNAs) are class of short, non-coding RNAs that play role in post-transcriptional gene expression. Studies showed that miRNAs play important roles in autoimmune disease by participating in differentiation and maturationof immune cells. miR-326 identified as a fundamental key for developing of T cell and differentiation of Th17. We searched PubMed and science direct search engines with the miR-326 and Multiple Sclerosis key words. We found 17 articles in PubMed until April 2019 and afterreading the titles and abstracts and excluding reviews, we include 8 articles. There were 26 articles in science direct since 2015 till April 2019 with research articles filter that after reading titles and abstracts there were only 3 articles left. Studies assess the level of miR-326in serum of MS patients and all the articles except one of them found overexpression of miR-326 in MS patients compared to controlled group. In one studies announced that relapse and remit phase of MS are distinguishable on the basis of miR-326 in serum. In some treatmentmethods (natalizumb and glucocorticoid) lower level of miR-326 showed after treatment. Most of the studies suggested that due to difficulties of current diagnostic methods of MS that based on symptoms, MRI and CSF analysis, we can evaluate miR-326 in patients’blood more convenient. Conclusion: on the basis of included articles, there is a correlation between MS and overexpression of miR-326. So miR-326 is a good biomarker for prognosis and monitoring of MS patients. Because of convenient detection of miRNAs as biomarkers for MS we suggest more studies in this field for other miRNAs which may have the same role.

نویسندگان

Parsa Shoqi

Student Research Committee, Mashhad Branch, Islamic Azad university, Mashhad, Iran

Mohamad Reza Khojasteh

Student Research Committee, Mashhad Branch, Islamic Azad university, Mashhad, Iran

Valareza Alizadeh

Department of Mashhad Neuroscience Research, Mashhad Branch, Islamic Azad University, Mashhad, Iran