The Beneficial Effect of Aminoguanidine on Learning and Memory Impairment in lipopolysaccharide Treated Rats
- سال انتشار: 1398
- محل انتشار: سومین همایش بین المللی التهاب سیستم عصبی و سومین فستیوال دانشجویی علوم اعصاب
- کد COI اختصاصی: NIMED03_228
- زبان مقاله: انگلیسی
- تعداد مشاهده: 359
نویسندگان
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
Psychiatry and Behavioral Sciences Research Center, Department of Neurocognitive Sciences, Mashhad University of Medical Sciences, Mashhad, Iran
Psychiatry and Behavioral Sciences Research Center, Department of Neurocognitive Sciences, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
In the present study, the effect of aminoguanidine (AG) as inducible NO synthase (iNOS) inhibitor on lipopolysaccharide (LPS)-induced learningand memory impairment was evaluated. Materials and Methods: The rats were divided into 5 groups and treated as follow: 1) Control (Saline), 2) LPS (1 mg/ kg), 3-5) AG 50, 100 and 150mg/kg 30 min before LPS injection. The treatment was started 5 weeks beforethe behavioral experiments and continued during the behavioral tests (LPS injection two h before each behavioral experiment). Results: The escape latency in Morris water maze (MWM) test and the latency to enter the dark compartment in Passive avoidance (PA) test in LPS group were significantly higher than in control (P< 0.001) whereas, in AG100-LPS and AG150-LPS groups they were shorter than LPS group(P< 0.001). Conclusion: It is suggested that LPS induced learning and memory impairments are preventable by aminoguanidine as an iNOS inhibitor.کلیدواژه ها
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