The Study of How to Articulate the Expression of Key Genes in Alzheimer،s Disease (AD) Bioinformatics Approaches and Analyzing Pathways Involved in Them
- سال انتشار: 1398
- محل انتشار: سومین همایش بین المللی التهاب سیستم عصبی و سومین فستیوال دانشجویی علوم اعصاب
- کد COI اختصاصی: NIMED03_209
- زبان مقاله: انگلیسی
- تعداد مشاهده: 425
نویسندگان
Department of Biochemistry, Najafabad Branch, Islamic Azad University, Najafabad, Iran
Department of Biotechnology, Nonprofit University of Ashrafi Esfahani, Esfahan, Iran
Department of Genetics, Falavarjan Branch, Islamic Azad University, Esfahan, Iran
Department of Biochemistry, Najafabad Branch, Islamic Azad University, Najafabad, Iran
چکیده
AD is a Multifaceted cognitivebehavioral disorders disease and its prevalence is increasing in today،s societies. AD is due to theaccumulation of a myloid proteins in the form of neurofibricular cavities (NFT) inside the neurons, and eventually disruption occurs in the cerebral blood flow. The patient suffers from a lack of memory, cognitive and behavioral abilities. Because of the disorder inlife, treatment is of great importance. Materials and Methods: By sites PubMed, Google scholar and MalaCards identified key genes of AD. Then the biology pathways of these genes were obtained and evaluated by NCBI. To investigate the role of miRNAs in AD miRWALK2.0 and miRNASNP databases were served to predict miRNA-target genes interactions. Results: The data showed that SOX9, SOX2 and CR1 genesare important in CNS that mutation causes oxidative stress, inflammatory processes and NFT generation. According to bioinformatics databases in SOX9 selected 3 single-nucleotide polymorphisms (SNP): rs1042673, rs1042667, rs74999341 and 3miRNA: hsa-let-7d-3pand -5p, has-miRNA-1181, hsa-miR-3117-3p and 5p. In SOX2 selected rs191376028 and hsa-miR-548d-5p and 3p. In CR1 selected 3SNP: rs47274776, rs66149234, rs41274776 and 3miRNA: hsa-miR-548o-3p, hsamiR- 665, hsa-miR-1323. The most Pathways biologicalinclude SOX9: cAMP and Hippo signaling organism specific biosystem, CR1: Legionellosis conserved biosystem and Hematopoietic cell lineage organism specific biosystem, SOX2: Regulating pluripotency of stem cells organism specific biosystem. Then the best interconnection networks were draw up. Conclusion: One can predict that by increasing the performance of these miRNAs can be set correctly biological pathways.کلیدواژه ها
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