Afsoon Dadvar - Student Scientific Research Center, Department of Neurology Zahedan University of Medical Sciences, Zahedan, Iran
Hamed Amirifard - Department of Neurology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Alireza Khosravi - Clinical Immunology Research Center, Department of Neurology, Zahedan University of Medical Sciences, Zahedan, Iran
Mahnaz Shahrakipour - Zahedan University of Medical Sciences, Zahedan, Iran

Multiple sclerosis (MS) is the most common nervous system disorder in youth.This sickness have a long-lasting and unspecified nature so it has many effects on life quality due to its numerous disabilities. Caffeine can stimulate central nervous system and improve nervous-muscle coordination; So we have decided to assess the effect of caffeine consumption on life quality in multiple sclerosis patients. Materialsand Methods: In this randomized clinical trial study, 30 multiple sclerosis subjects were selected. the assessment method of symptoms improvement is based on before and after caffeine consumption.at first subjects were screened based on the entrance criteria includes agebetween 15-60, weight above 45, not using the equal dose of caffeine and substances preferred by study. And the exclusion criteria includes allergic reaction and feeling discomfort or getting worse. At the first two weeks the patients got placebo and after that they filled the quality of life questionnaire (SF-26) and the results were recorded. After that they got 200 mg caffeine daily and the SF-26 questionnaire were filled in weeks 4,8,12 and the results were recorded. IRCT Code: 2017012332142N1 Results: This study was conductedon 30 patients with MS (23 female and 7 male) with the average age of 38.8. Mean SF-26 score in each 4 stage were respectively 73.5,77.05,77.11,74.83. the result of analyzed frequent measurement indicated that significant changes were made in their quality of life(p= 0.031). Conclusion: According to the present study, there is a significant relation between quality of life and caffeine consumption. Based on two by two comparisons it can be concluded that 12 weeks caffeine consumption has a significant effect on quality of life in patients withmultiple sclerosis. More studies with larger sample size is recommended to evaluate the results of this study.