Inflammatory Factors in Endometriosis

Background: Endometriosis affects up to 15 % of reproductive age women. The growth of endometrial epithelial and stromal cells outside the uterine cavity characterizes the endometriosis. It is associated with chronic pelvic pain, infertility and reduced quality of life. The histogenesis of endometriosis remains un-clear, accumulating evidence indicates that combinations of hormonal, immunologic, genetic and environmental factors are involved in the origin and development of endometriosis. In this article, an overview to identify an association between altered serum inflammatory factors and endometriosis.Materials and Methods: A literature search was conducted through ScienceDirect.Results: Endometriosis is a chronic local inflammatory disease and alterations in the immune system might play an important role in its pathogenesis. The growth of endometriotic lesions relies on estrogen. These lesions increase pro-inflammatory cytokine, chemokine and growth factor concentrations in the local environment. It has been evidenced that the expression of some inflammatory factors including interleukin (IL) IL-1, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-13, IL-15, IL-17, IL-18, 1L-27, and IL-37, in the serum, peritoneal, and follicular fluid of women with endometriosis differs from that of women with-out this condition. Previous studies have demonstrated a role for elevated chemokines and MMPs in endometriosis lesions, peritoneal fluid, and peritoneal macrophage gene expression. there are at least six (CXCL1, CXCL8, CXCL13, CXCL14, CCL2, and CCL5) different chemokines that were evaluated in association with infertility. the pelvic fluid concentration of the B-chemokine CCL5, also called RANTES (Regulated upon Activation, Normal T Cell Expressed and Secreted), was sig-nificantly elevated in women with endometriosis. and that these levels correlated positively with the stage of the disease MCP-1 (monocyte chemotactic protein-1) or B-chemokine CCL2 and Eotaxin – or CCL11 – is another B-chemokine (CC chemokine) in women with endometriosis increase in the peritoneal fluid that correlates with the severity of the disease.Conclusion: It is imperative that we now understand that en-dometriosis is a complex and possibly a systemic disease, with multiple factors involved in its pathophysiology. A panel of bio-markers will most be necessary to diagnose and treat a complex disease such as endometriosis.

کلیدواژه ها:

Endometriosis ، Inflammatory Factor ، Etiology of En-dometriosis