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Effects of Biolozax-H on The Testis Structure and Pi-tuitary- Gonadal Hormones in Adult Rat following Treat-ment with Clinical Dose

عنوان مقاله: Effects of Biolozax-H on The Testis Structure and Pi-tuitary- Gonadal Hormones in Adult Rat following Treat-ment with Clinical Dose
شناسه (COI) مقاله: RROYAN20_315
منتشر شده در بیستمین کنگره بین‌المللی بیولوژی تولید مثل و پانزدهمین کنگره بین‌المللی سلول های بنیادی در سال 1398
مشخصات نویسندگان مقاله:

K Kouhestanian - Department of Biology, Azad University of Mashhad, Mashhad, Iran
J Khayat Zadeh - Department of Biology, Azad University of Mashhad, Mashhad, Iran
S Zafar- Balanezhad - Department of Biology, Azad University of Mashhad, Mashhad, Iran

خلاصه مقاله:
Background: The activity of the renin-angiotensin system has an effect on oxidative stress in many tissues, including the tes-tes. Therefore, in this study, the biolozax-H drug, which has an effect on the spermatogenesis activity and Pituitary- Gonadal Hormones in male rats, is further investigated.Materials and Methods: Male adult rat (200-250 g) were di-vided into two groups of sixteen each. Control and biolozax-H treated group were administered 20 mg/kg biolozax-H for 45 days, respectively. The animals were sacrificed 45 days after starting treatment. The histological change on germinal epithe-lium, and Level of hormones was measured by Radioi Immuno Assay (RIA) method. Then, tissues were fixed in Buin s fixa-tive. Sections were cut into 5 μm thicknesses and stained with Hematoxylin and Eosin (H& E). The achieved results were ana-lyzed in SPSS software using t-test and ANOVA.Results: Count of spermatogenic, Sertoli and leydig cells significantly decreased in the experimental group in com-parison with the control and Control groups (P<0.05).also In the experimental group,titer of FSH, LH and testoster-one hormone decreased significantly (P<0.05) in comparison with Control.Conclusion: Regarding physiological role of Sertoli cells dur-ing spermatogenesis, reduction of FSH hormone may lead to negative effects on the sperm production and reproductive po-tential of male Rat.

کلمات کلیدی:
Biolozax-H, Sperm Viability, Testis, FSH, LH

صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/950438/