Effect of Pentoxifylline on Tumor Necrosis Factor and Reactive Oxygen Species Levels in Seminal Plasma in Idi-opathic Male Infertility
- سال انتشار: 1398
- محل انتشار: بیستمین کنگره بین‌المللی بیولوژی تولید مثل و پانزدهمین کنگره بین‌المللی سلول های بنیادی
- کد COI اختصاصی: RROYAN20_292
- زبان مقاله: انگلیسی
- تعداد مشاهده: 340
نویسندگان
Department of Biology, Arak university, Arak, Iran
Department of Biology, Arak university, Arak, Iran
Department of Biology, Arak university, Arak, Iran
Department of Urology, Lorestan University of Medical Science, Khorram Abad, Iran
چکیده
Background: Pentoxifylline is a methyl xanthine derivative that influences the sperm motion characteristics. It is commonly used in treatment of male-factor infertility, including astheno-zoospermia. The aim of this study was to evaluate any possible effect of Pentoxifylline on sperm characteristics ،TNF(Tumor Necrosis Factor) and ROS (Reactive Oxygen Species) Levels in Seminal Plasma in a group of patients with asthenozoospermia. Materials and Methods: 30 infertile men with asthenozoo-spermia were allocated to this study. A dosage of 400 mg pen-toxifylline / twice daily for duration of 3 months was adminis-tered to each patient. Two semen samples (one before and one after the pentoxifylline therapy) were evaluated under blind condition. Semen parameters ,TNF and ROS Levels( by hu-man TNF ELISA kit and Chemiluminescence assay- Agarwal respectively) in Seminal Plasma were analyzed ( pre and post intervention) for each sample. Data was analyzed statistically using one-way ANOVA and Tukey’s test .Results: Pentoxifylline increased significantly the mean sperm count and normal morphology in the men with asthenozoo-spermia when compared to pre-administration. pentoxifylline was significantly effective on the fast progressive motility of sperm (P< 0.01). Based on the results, mean concentration (± S.D) of TNF in the seminal plasma was significantly in-creased in patients treated with pentoxifylline when compared to pre-administration. Moreover, ROS levels in seminal plasma of patients with asthenozoospermia decreased significantly compared to before administration of pentoxifylline.Conclusion: Although our results demonstrate that oral therapy of pentoxifylline significantly increase the quality of sperm, es-pecially motility from infertile men with asthenozoospermia, but more molecular studies are needed to elucidate the safety of pentoxifylline- administration.کلیدواژه ها
Pentoxifylline, Seminal Plasma, Asthenozoospermia, Infertilityمقالات مرتبط جدید
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.