Interleukins in diagnosis of perinatal asphyxia: A systematic review

سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 439

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شناسه ملی سند علمی:

JR_IJRM-17-5_001

تاریخ نمایه سازی: 28 مهر 1398

چکیده مقاله:

Background: Biochemical markers including interleukins (ILs) has been proposed forearly diagnosis of asphyxia.Objective: This study has aimed to systematically review the significance of ILmeasurements in the diagnosis of perinatal asphyxia.Materials and Methods: PubMed, Cochrane Library, Web of Science, Embase, andScopus databases before 2017 were searched for the following keywords: asphyxia,neonatal, interleukin, and diagnosis. A total of 13 out of 300 searched papers werefinally selected for evaluation. Interleukins under study were IL6 and interleukin. Interleukins had been measured in 10 studies by serum samples, 2 studies bysamples of Cerebro Spinal Fluid (CSF), and 1 study by sample of umbilical cord blood.The inclusion criteria were: studies on neonates, with adequate information from thetest results and studies using markers other than ILs to detect asphyxia; however,studies with only abstracts available were excluded.Results: Research on the issue suggests that IL6 > 41 Pg/dl has the sensitivity of 84.88%and the specificity of 85.43%, whereas IL-1B > 4.7 Pg/dl has the sensitivity of 78%and specificity of 83% in the diagnosis of neonatal asphyxia. Among diagnostic ILsfor neonatal asphyxia, combination of IL6 and IL-1B had the highest sensitivity, that is,92.9%.Conclusion: IL6 and IL-1B of serum samples were used in the early diagnosis ofperinatal asphyxia and are useful predictors for the outcomes of perinatal asphyxiaand its intensity. In addition, simultaneous evaluation of IL-1B and IL6 can improve thesensitivity of the early diagnosis of perinatal asphyxia.

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نویسندگان

Hassan Boskabadi

M.D., Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Ali Moradi

Ph.D., Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Maryam Zakerihamidi

Ph.D., Department of Midwifery, Faculty of Medical Sciences, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran