Antidiabetic effect of hydro-alcoholic extract of Eryngium billardieri in streptozotocin-induced diabetic mice

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 608

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شناسه ملی سند علمی:

AMSMED20_077

تاریخ نمایه سازی: 22 مهر 1398

چکیده مقاله:

Background and Aim : Eryngium with 274 species, is the largest genus of Apiaceae family. Nine species of this herbaceous plant grow in Iran that Eryngium billardieri is one of these species. The purpose of this study was to evaluate anti-diabetic effect of Eryngium billardieri extract in streptozotocin induced diabetic mice. Material and Methods: Air dried aerial parts of Eryngium billardieri were grinded and maceration extracted using ethyl alcohol 70%. In this study, 40 male NMRI mice in 4 groups (n=8) were selected including: 1: Healthy control group, 2: Diabetic control group, 3, 4: Diabetic groups which received 100 and 300 mg/kg IP (Intra Peritoneal) injection of plant extract for 21 day, respectively. Diabetes was induced by IP injection of streptozotocin (150 mg/kg single dose) (2). At the end of study, blood and liver samples were collected for measuring of blood sugar, OGTT (Oral Glucose Tolerance Test) and insulin. Analysis of data was evaluated through SPSS, version 24. Results: Extract at 100 and 300 mg/kg doses for 21 days did not significantly reduce blood glucose levels compared to streptozotocin (STZ) group. In the OGTT test, the extract of 100 mg/kg doses during time did not significantly reduce blood glucose levels compared to the dose of 300 mg/kg, in other words, the effect of the high dose extract on reducing blood glucose was more than the low dose. Extract at dose of 100 mg/kg caused decrease in weight of diabetic mice in 21 days compared to the STZ group (P<0.05). On the other hand, any of the doses could reduce the blood sugar (BS) level in comparison to streptozotocin group. Conclusion: IP injection of the extract does not decrease the blood sugar of diabetic mice. In the OGTT test, dose 300 mg/kg decreases glucose levels in diabetic mice. Dose 100 mg/kg causes a significant decrease in the weight of diabetic mice (P<0.05)

نویسندگان

Elaheh Touri

Faculty of pharmacy, Tabriz University of Medical Science, Tabriz, Iran

Parina Asgharian

Drug Applied Research Center, Tabriz University of Medical Science, Tabriz, Iran

Haleh Vaez

Faculty of pharmacy, Tabriz University of Medical Science, Tabriz, Iran

Alireza Garjani

Faculty of pharmacy, Tabriz University of Medical Science, Tabriz, Iran.Student Research Committee, Tabriz University of Medical Science, Tabriz, Iran