Myelin enhancement of Multiple sclerosis model with gold nanoparticles into the corpus callosum

سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 339

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شناسه ملی سند علمی:

JR_NAMJ-6-4_010

تاریخ نمایه سازی: 20 مهر 1398

چکیده مقاله:

Objective(s): With no substantial cost, we injected L-arginine into the rat’s corpus callosum (CC) to create animal model of multiple sclerosis (MS) and investigated the pre-injection effect of gold nanoparticles (GNPs). Materials and Methods: Adult male Wistar rat (250-300 g) was surgically cannulated at the CC, and after recovery it was injected L-arginine (3-200 µg/rat, intra-CC) once daily for 3 to 5 consecutive days. GNPs (0.001-0.01 µg/rat, intra-CC) were injected alone or prior to the L-arginine using the same procedure. Control group solely received saline (1 µL/rat, intra-CC). Brain was studied with luxol fast blue. Weight change was also analyzed via the analysis of variance (ANOVA). Results: L-arginine significantly induced (p< 0.05) a reduction in the fiber density while the neurons increased (p< 0.05). Single GNPs reduced (p< 0.05) the fiber and neuron densities; however, pre-injection of NPs caused myelinated fibers and uniform density of neurons. Conclusion: The L-arginine may trigger demyelination by pro-inflammatory nitric oxide (NO), and the GNPs may improve this effect.

نویسندگان

Mahjabin Khosravi

Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran

Manizheh Karami

Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran

Mohammadreza Jalali Nadoushan

Department of Pathology, Faculty of Medicine, Shahed University, Tehran, Iran

Abazar Hajnorouzi

Department of Physics, Faculty of Basic Sciences, Shahed University, Tehran, Iran

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