A Case of Metformin-Related Megaloblastic Anemia Presenting with Palpitation
- سال انتشار: 1394
- محل انتشار: مجله ایمنی و بهبود بیمار، دوره: 3، شماره: 2
- کد COI اختصاصی: JR_PSQ-3-2_008
- زبان مقاله: انگلیسی
- تعداد مشاهده: 291
نویسندگان
Atherosclerosis Prevention Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
چکیده
Introduction:Metformin is the cornerstone of medical treatment in most diabetic patients with many beneficial effects on cardio-metabolic parameters. However, long term metformin is a known pharmacological cause of vitamin B12 deficiency leading to neurological symptoms, megaloblastic anemia and increased levels of serum homocysteine. Moreover, it is well known that vitamin B12 deficiency-induced neurologic symptoms precede the appearance of megaloblastic anemia. Case:We herein report the case of an old woman with a history of long term metformin consumption who visited the cardiology clinic with the chief complaint of palpitation due to megaloblastic anemia without any neuropsychiatric symptoms. She was successfully treated with a parenteral regimen of vitamin B12 within two months. Conclusion:Although annual measurement of serum vitamin B12 levels could be considered in patients on long-term metformin therapy, yet it seems more reasonable and cost-effective to prevent vitamin B12 deficiency and its related adverse effects with annual prescription of parenteral vitamin B12 in all such patients.کلیدواژه ها
Megaloblastic Anemia, Metformin, Vitamin B12 Deficiencyاطلاعات بیشتر در مورد COI
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