Effect of Treatment with Vitamin D on Maternal and Neonatal Indices in Pregnant Women with Hypocalcemia: A Randomized Controlled Trial
- سال انتشار: 1396
- محل انتشار: مجله بین المللی کودکان، دوره: 5، شماره: 9
- کد COI اختصاصی: JR_INJPM-5-9_015
- زبان مقاله: انگلیسی
- تعداد مشاهده: 408
نویسندگان
Assistant Professor of Gynecology and Obstetrics, Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Associate Professor of Endocrinology, Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
General Practitioner, Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Professor of Endocrinology, Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
چکیده
Background The impact of concomitant vitamin D deficiency and maternal hypocalcemia on fetal growth has is not clear. The aim of this study was to determine the effect of treatment with vitamin D on maternal and neonatal indices in pregnant women with hypocalcemia. Materials and Methods This clinical trial was conducted on 110 pregnant women (22-26 weeks of gestational age) with simultaneous mild hypocalcemia (8 < serum calcium< 8.5 mg/dL) and vitamin D deficiency (25 (OH) D< 75 nmol/L). The study subjects were randomly allocated to intervention (n=55) and control (n=55) groups. In the control group, the subjects were given daily prenatal capsule until delivery. In the intervention group, the subjects were given 50,000 Units vitamin D weekly for eight weeks in addition to prenatal capsules until delivery similar to the control group. At delivery, maternal calcium and 25 (OH) D level and neonatal indices (weight, height, and head circumference) were measured and compared between the groups. Results At delivery, mean maternal vitamin D level was 97.5±23.4 nmol/L in the intervention group and 48.9±17.2 nmol/L in the control group, respectively (P< 0.001). Mean maternal calcium level in the intervention group was higher than the control group (9.0±0.6 mg/dl vs. 8.8±0.5 mg/dl) but the difference was not statistically significant (P> 0.05). Mean neonatal weight, height, and head circumference were not significantly different between the two groups (P> 0.05). Conclusion In pregnant women with mild hypocalcemia, treatment with vitamin D would not have effect on mean serum calcium and neonatal indices.کلیدواژه ها
body height, body Weight, Hypocalcemia, pregnancy, Vitamin D deficiencyاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.