The Effect of MMP9 in the Development of Colorectal Cancer Progression
- سال انتشار: 1395
- محل انتشار: فصلنامه بین المللی تحقیقات پزشکی، دوره: 5، شماره: 3
- کد COI اختصاصی: JR_INTJMI-5-3_007
- زبان مقاله: انگلیسی
- تعداد مشاهده: 347
نویسندگان
Department of pathology, Gastrointestinal cancer research center, Imam Khomeini hospital, Mazandaranuniversity of medical sciences,Iran
Department of pathology, Imam Khomeini hospital, Mazandaran university of medical sciences,Iran
Department of pathology, Imam Khomeini hospital, Mazandaran university of medical sciences,Iran
چکیده
Objective: Matrix metalloprotease 9 (MMP9) is a group of proteolytic enzymes that mediate breaking down thecomponents of the fibrillar extracellular matrix during tissue rearrangement,physical,biological and pathologicalconditions such as growth, wound healing, inflammation and tumor progression. To investigate the associationof these markers with clinicopathologic features and survival of colorectal cancers(CRC),we examined itsexpression in colorectal cancer tissues.Methods: The expression of MMP9 in 91 paraffin embedded specimens of colorectal cancer and normal tissueadjacent to the tumor of patients referred to Imam Khomeini Hospital in Sari,Iran was studiedimmunohistochemically and the relationship between the clinical data and pathological features wereconsidered,too.Result: 91 samples (43 women and 48 men) were studied including 6 mucinous carcinoma and 88adenocarcinoma. MMP9 expression was negative and positive in 31 and 66 cases respectively. Expression ofMMP9 in normal tissue around the tumor was 5.5%. Our finding revealed that the MMP9 correlatedsignificantly with tumor depth (p-value: 0.033) and metastasis to lymph node (p-value: 0.007). The associationof MMP9 expression with the other clinicopathologic factors was not statistically significant (p-value> 0.05).Conclusion: According to this study,the relationship between the expression of MMP9 with lymph nodemetastasis and depth of tumor was observed. To confirm the result, vast studies with more samples and alsowith the other matrix metalloproteinase proteases is recommended.کلیدواژه ها
Colorectal Cancer,MMP9,Clinicopathology,Immunohistochemistry,Metastasisاطلاعات بیشتر در مورد COI
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