Case report: A 27 years old woman with brain metastases of synovial sarcoma

A 27- year old lady with severe headache, nausea, vomiting and impaired cerebellar function. She had a historyof a left arm synovial sarcoma and she was evaluated with magnetic resonance imaging (MRI) that shows agadolinium enhanced mass measuring about 7 mm in diameter with both solid and cystic portions in leftcerebellar hemisphere causing mass effect. Histologic evaluation confirmed poorly differentiated type synovialsarcoma composed of tumor cells containing pleomorphic round to oval hyper chromatic to vesicular nucleiwith coarse chromatin and a little light eosinophilic cytoplasm. The IHC stain is done and showed EMA, CKand vimentin positivity in tumor cells. The patient was treated with surgery, chemotherapy and radiotherapy. Inthe follow up study at 6 month post chemotherapy evaluation computed tomography (CT scan) showedpulmonary metastases and transthoracic biopsy revealed the same pathologic feature. According to our patient,brain metastasis could occur even in extremities synovial sarcoma and so CNS imaging as screening may beintroduced in follow up plan of these patients.

کلیدواژه ها:

synovial sarcoma ، brain metastases ، pulmonary metastases