Evaluation of the Association between the C۶۷۷T Polymorphism of Methylenetetrahydrofolate Reductase Gene and Recurrent Spontaneous Abortion
- سال انتشار: 1393
- محل انتشار: مجله علمی ناباروری ایران، دوره: 5، شماره: 1
- کد COI اختصاصی: JR_IRJN-5-1_002
- زبان مقاله: انگلیسی
- تعداد مشاهده: 391
نویسندگان
M.Sc. of Biology-Genetics, Tehran Science and Research Branch of Islamic Azad University, Tehran, IRAN
B.Eng. of Industrial Engineering, Iran University of Science and Technology (IUST), Tehran, IRAN
Ph.D. of Public Law, Tehran Science and Research Branch of Islamic Azad University, Tehran, IRAN
چکیده
Introduction: One factor known to cause thrombophilia in women with unexplained recurrent spontaneous abortion (RSA) is C۶۷۷T polymorphism of methylenetetrahydrofolate reductase gene. This study aimed to determine the association between RSA and MTHFR C۶۷۷T polymorphism in Iranian patients. Methods: In this case-control study, ۳۰ patients with previous history of two or more consecutive unexplained abortions, and ۱۰ women with at least two live births without a miscarriage were analyzed for MTHFR C۶۷۷T polymorphism using PCR-RFLP (PCR-Restriction Fragment Length Polymorphism) method; the study was carried out on patients referring to Baqiyatallah Hospital and Avicenna Infertility Clinic. The results obtained via estimating the genotype of each polymorphism were analyzed by SPSS version ۱۶. Results: Seventeen women (۵۶.۶ %) with recurrent spontaneous abortions and ۵ women (۵۰ %) from the control group were heterozygous for MTHFR C۶۷۷T polymorphism. T-allele frequency in the experiment group was higher than the control group (۲۸.۴ % and ۲۵ % for the experiment and control group, respectively). Conclusion: The prevalence of MTHFR C۶۷۷T polymorphism was slightly higher in RSA patients compared with the controls. This finding failed to support the relationship between this polymorphism and the increasing risk of RSA in the evaluated Iranian women.کلیدواژه ها
Methylenetetrahydrofolate reductase (NADPH۲), Polymorphism (genetics), Spontaneous abortion, Thrombophiliaاطلاعات بیشتر در مورد COI
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