Myocardial Perfusion Gated SPECT of patients with known or suspected coronary artery disease in Raaheaseman Center of Nuclear Medicine : effect of gender and age

Introduction : Myocardial Perfusion Gated SPECT has effective output for patient with coronary artery disease (CAD) in diagnostic and prognostic. It is an accurate method for assessment of myocardial perfusion (MP), left ventricle ejection fraction (LVEF), end-diastolic volume (EDV) and end-systolic volume (ESV). According to recent studies that mentioned the effect of gender on LV function, the aim of this study was to investigate the effect of gender on the Gated SPECT images of patients with heart diseases at the Raaheaseman Nuclear Medicine Center.Methods:In this research, Gated SPECT studies of 631 patients with average of 57 years old that were underwent myocardial perfusion scan in the early six months of the center s launch were used. Subsequently, based on interpretation of physician, scans with abnormal diagnosis (132 male and 106 women) were separated from the rest of the scans and quantitative information of left ventricular for each patient were extracted and then the comparison was made based on gender and age.Results:There was a significant difference in end systolic and diastolic volumes (ESV & EDV) between males and females, while gender had no significant effect on left ventricle ejection fraction. Results demonstrate that despite the good ejection fraction, the end systolic and end diastolic volume has been very low. The mean end systolic and end diastolic volumes for females respectively were 23.88 and 68.27, (EF=60.76%), while for males were, 38.88 and 90.6 (EF=57.19%).Conclusion:According to the findings, it can be concluded in men despite a similar amount of EF to women, ESV & EDV was higher. Women also get ischemia in the higher ejection fraction than men and after Gated SPECT output clinical history, age and history of CAD are more relative for prediction.

کلیدواژه ها:

Gated SPECT ، CAD ، Myocardial perfusion ، Age ، Gender