Effect of curcumin, the active constituent of turmeric, on penicillin-induced epileptiform activity in rats
- سال انتشار: 1391
- محل انتشار: مجله گیاهان دارویی ابن سینا، دوره: 2، شماره: 4
- کد COI اختصاصی: JR_AJP-2-4_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 324
نویسندگان
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia ۵۷۱۵۳-۱۱۷۷, I.R. Iran
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia ۵۷۱۵۳-۱۱۷۷, I.R. Iran
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia ۵۷۱۵۳-۱۱۷۷, I.R. Iran
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia ۵۷۱۵۳-۱۱۷۷, I.R. Iran
چکیده
Objective: Curcumin is a major constituent of turmeric and has many biological functions such as anticancer and anti-inflammatory effects. The present study was conducted to investigate the effects of curcumin and diazepam in separate and combined treatments on penicillin-induced seizures in rats. Materials and Methods: In urethane-anesthetized rats, epileptiform activity was induced by intracortical (i.c.) administration of penicillin (200 IU, 1 µl), and frequency and amplitude of spike waves were analyzed using electrocorticographic recordings. Results: Intraperitoneal (i.p.) injections ofcurcumin at doses of 100 and 200 mg/kg, and intracerebroventricular (i.c.v.) injection of diazepam at a dose of 5 µg significantly (p< 0.05) reduced both frequency and amplitude of spike waves. Co-administrations of curcumin (50 mg/kg, i.p.) with diazepam (5 µg, i.c.v.) enhanced the antiepileptic effect of diazepam (5 µg, i.c.v.). Conclusion: The results suggested that both curcumin and diazepam suppressed penicillin-induced epileptiform activity. A potentiation effect was observed between curcumin and diazepam in reducing penicillin-induced seizures.کلیدواژه ها
Curcumin, Diazepam, Penicillin-Induced Seizures, Ratsاطلاعات بیشتر در مورد COI
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