Preventive effects of hydroalcoholic extract of saffron on hematological parameters of experimental asthmatic rats
- سال انتشار: 1392
- محل انتشار: مجله گیاهان دارویی ابن سینا، دوره: 3، شماره: 3
- کد COI اختصاصی: JR_AJP-3-3_010
- زبان مقاله: انگلیسی
- تعداد مشاهده: 391
نویسندگان
Department of Biology, Payame Noor University, Boshruyeh, South Khorasan, I. R. Iran
Applied Physiology Research Centre and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
Department of Biology, Faculty of Science, Mashhad Branch, Islamic Azad University, Mashhad, I. R. Iran
Department of Biology, Faculty of Science, Arsanjan Branch, Islamic Azad University, I. R. Iran
چکیده
Objective: Asthma is a chronic inflammatory disease of the respiratory airways distinguished by edema and infiltration of inflammatory immune cells. To test our hypothesis about the anti-inflammatory effect of saffron, we examined effects of Crocus sativus (C. sativus) extract as a prophylactic anti-inflammatory agent in sensitized rats. Materials and Methods: To induce experimental asthma, rats were sensitized with injection and inhalation of ovalbumin (OA). Forty male Wistar rats were divided into 5 groups (n=8 for each): control, sensitized (asthma), and sensitized and pretreated with three different concentrations of extract, 50, 100, and 200 mg/kg, 2 times a week (group asthma+50EX, group asthma+100EX, and group asthma+200EX). After 32 days, total white blood cells (WBC) counts, red blood cells (RBC), and platelet counts in blood were examined. Results: Total WBC number and eosinophil and neutrophil percentage in blood were increased, but lymphocyte decreased in sensitized animals compared with those of control group (pConclusion: Our findings indicated that the extract of C. sativus could be useful to prevent asthma as an anti-inflammatory treatment.کلیدواژه ها
Asthma, Crocus sativus, Inflammation, Rat, Sensitization, WBCاطلاعات بیشتر در مورد COI
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