The HER-2 as a Target Gene of Curcumin to Protect Hepatocytes Against the Arsenic-induced Carcinoma in Mice
- سال انتشار: 1396
- محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 12، شماره: 2
- کد COI اختصاصی: JR_IJP-12-2_010
- زبان مقاله: انگلیسی
- تعداد مشاهده: 382
نویسندگان
Dept. of Biology, Faculty of Biological Sciences, Parand Branch, Islamic Azad University, Parand, Iran
Dept. of Biology, Faculty of Biological Sciences, Parand Branch, Islamic Azad University, Parand, Iran
Dept. of Biology, Faculty of Biological Sciences, Parand Branch, Islamic Azad University, Parand, Iran
چکیده
Background & objective: The HER-2 gene is an important on co protein overexpressed in many types of cancers. The current study hypothesized that curcumin downregulates HER-2 and inhibits the signal transduction pathway of PI3K/Akt, MAPK, and activation of NFκB, which could be useful to treat overexpressed-HER-2 hepatocellular carcinoma (HCC). Methods: In the current study, 40 male NMRI (Naval Medical Research Institute) mice were divided into 4 groups of 10 as follow: Group1 (control group) only received 5 mL/kg corn oil, group 2 (poisoned group) received 30 mg/L arsenic (As2O3) dissolved in water, group3 (curcumin treated), and group 4 (curcumin and arsenic treated) received 10 to 20mg/5mL/kg for 60 days. Once experimental period was completed, liver samples were collected. The analysis of the gene expression was performed by real-time polymerase chain reaction (PCR) technique. Results: Gene expression analysis showed that curcumin had significantly downregulated the activity of HER-2, in poisoned mice. Conclusion: According to the current study results, it could be concluded that curcumin has the inhibitory potential toward HER-2-overexpressed HCC.کلیدواژه ها
Her2, Hepatocellular Carcinoma, curcumin, Arsenicاطلاعات بیشتر در مورد COI
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