Synthesis of Halloysite/Zein Nanocomposite for Controlled Drug Delivery of Phenobarbital Sodium

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 395

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شناسه ملی سند علمی:

ISOC26_215

تاریخ نمایه سازی: 2 شهریور 1398

چکیده مقاله:

Today, Halloysite nanotubes (HNTs) are used due to its high internal diameter, abundance,non-toxicity, high compatibility and availability in drug release systems. By adding a coat andsynthesis a nanocomposite, the release rate of the drug can be further reduced. In this study,zein protein was used for coating and fabricate nanocomposites. Fabrication of nanocompositeswas done via creating an electrostatic force between Halloysite and Zain via adjustingthe pH via layer by layer synthesis. Synthesis of nanocomposite was assessed by FT-IR, Zetapotential, scanning electron microscopy, dynamic light scattering, X-ray diffraction, differentialscanning calorimetry, and thermogravimetric analysis. Then, loading and release of thephenytoin sodium from pure nanotubes and nanocomposites was investigated using Ultraviolet-visible spectrophotometry. The results showed that the loading of the drug by the nanocompositewas twice as high as the loading of pure halloysite. The release rate of the drug alsodropped dramatically, so that 50% of the drug loaded in halloysite was released in the firsthour and the same amount of drug was released from the nanocomposite within 9 hours.

نویسندگان

Mehdi Zangene

Department of Chemistry, Amirkabir University of Technology, Iran

Majid Abduss

Department of Chemistry, Amirkabir University of Technology, Iran

Alireza Mohebali

Department of Chemistry, Amirkabir University of Technology, Iran