Antioxidant Function and β-LG Interactions of Zinc(II) Dithiocarbamate Complex
محل انتشار: بیست و ششمین سمینار شیمی آلی ایران
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 333
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شناسه ملی سند علمی:
ISOC26_183
تاریخ نمایه سازی: 2 شهریور 1398
چکیده مقاله:
A new dithiocarbamate complex was synthesized and characterized (Fig. 1) [1]. The in vitroantioxidant activity of Zn(II) complex was measured against 1,1-diphenyl-2-picrylhydrazylradicals (IC50 = 36 mg L-1). The interaction of the complex with bovine β-lactoglobulin (β-LG) presented that Zn(II) complex strongly quenched the fluorescence of carrier protein instatic quenching mode. Thermodynamic analysis indicated that complex binding βLG wasdriven by favorable enthalpy and unfavorable entropy, and the major driving forces were hydrogenbonding and Van der Waals forces. The results of FT-IR and UV–visible measurementsillustrated that the binding of complex to β-LG may induce conformational and microenvironmentalchanges of studied protein [2]. Molecular docking analysis confirmed thatZn(II) complex binds to residues located in the site II of β-LG.
نویسندگان
Fereshteh Shiri
Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran
Somayeh Shahraki
Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran
Hossein Forouzandeh- Moghadam
Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran