Antioxidant Function and β-LG Interactions of Zinc(II) Dithiocarbamate Complex

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 333

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شناسه ملی سند علمی:

ISOC26_183

تاریخ نمایه سازی: 2 شهریور 1398

چکیده مقاله:

A new dithiocarbamate complex was synthesized and characterized (Fig. 1) [1]. The in vitroantioxidant activity of Zn(II) complex was measured against 1,1-diphenyl-2-picrylhydrazylradicals (IC50 = 36 mg L-1). The interaction of the complex with bovine β-lactoglobulin (β-LG) presented that Zn(II) complex strongly quenched the fluorescence of carrier protein instatic quenching mode. Thermodynamic analysis indicated that complex binding βLG wasdriven by favorable enthalpy and unfavorable entropy, and the major driving forces were hydrogenbonding and Van der Waals forces. The results of FT-IR and UV–visible measurementsillustrated that the binding of complex to β-LG may induce conformational and microenvironmentalchanges of studied protein [2]. Molecular docking analysis confirmed thatZn(II) complex binds to residues located in the site II of β-LG.

نویسندگان

Fereshteh Shiri

Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran

Somayeh Shahraki

Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran

Hossein Forouzandeh- Moghadam

Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran