Green Multi-Component Reaction of α-Haloketoneswith Acetylenic Esters in the Presence of Papaverine (Poppy alkaloid)

Multi-component reactions (MCRs) are useful organic reactions in which three or morestarting materials react to give a product [1]. A poppy plant consists a lot of alkaloids and thisplant has been used for medical purposes since ancient times.Some opium alkaloid derivativeshave been medicinal properties, including oxycodone, oxymorphon, buprenorphine, nalbuphon[2-4]. In continuation of our quest for the synthesis of heterocyclic compounds [5], herein we describe a three-component condensation of α-haloketones1react with acetylenic esters2inthe presence of papaverine 3in water at room temperature by vigorous stirring to affordproducts 4in good to high yields.