One-Pot, Four-Component Synthesis of Pyrano[2,3-c]pyrazoles Catalyzed by Vanadium Oxo Pyridinoporphyrazine

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 275

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شناسه ملی سند علمی:

ISOC26_087

تاریخ نمایه سازی: 2 شهریور 1398

چکیده مقاله:

Tetrapyridinoporphyrazines are derivatives of phthalocyanines which have pyridine rings insteadof outerbenzene rings [1]. Porphyrazines containing metal ions such as Zn(II), Ni(II),Cu(II) are strongly stabile. This situation is very important for the application this macrocycliccomplexes as a stable catalyst in organic reactions. Pyrazole derivetives are the significantkind of heterocyclic compounds that feature in several pharmaceutical targets and naturalproducts of medicinal interest. Dihydropyrano[2,3-c]pyrazole derivatives have showed a widevariety of biological activities counting anticancer, antimicrobial, anti-inflammatory, insecticidal,and molluscicidal activities. In continuation of our efforts to synthesize of novel catalysts[2] and multicomponent reactions we wish to report the synthesis of vanadium-oxotetrapyridinoporphyrazine [VO(TPPA)] as an efficient catalyst for the synthesis of dihydropyrano[2,3-c]pyrazole through the condensation reaction of aryl aldehydes, ethyl acetoacetate,malononitrile, and phenyl hydrazine under solvent free condition at 60 °C (Fig. 1).

نویسندگان

Maliheh Safaiee

Department of Chemistry, University of Nahavand, Nahavand, ۶۵۹۳۱۳۹۵۶۵, Iran

Mahtab Moeinimehr

Department of Chemistry, University of Nahavand, Nahavand, ۶۵۹۳۱۳۹۵۶۵, Iran

Masumeh Seif

Department of Chemistry, University of Nahavand, Nahavand, ۶۵۹۳۱۳۹۵۶۵, Iran