Co(NO3)2.6H2O: A Mild, Efficient and Novel Catalyst for the One-Pot Synthesis of Tetrahydrobenzo[b]pyran Derivatives

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 380

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شناسه ملی سند علمی:

ISOC26_030

تاریخ نمایه سازی: 2 شهریور 1398

چکیده مقاله:

Recently, tetrahydrobenzo[b]pyran derivatives are known as an important class of heterocyclicscaffolds in the field of drugs and pharmaceuticals [1]. These compounds exhibit significantbiological properties such as antibacterial, antitumor, anti-allergic, antibiotic, hypolipidemicand immunomodulating activates [1-3]. In this paper, we want to report a one pot reactionfor the synthesis of tetrahydrobenzo[b]pyran derivatives using dimedone (1 mmol),malonitrile (1 mmol), aldehyde (1 mmol) in the presence of a catalytic amount (20 mol%) ofCo(NO₃)₂.6H2O in EtOH: H2O at 70 °C. The advantages of this method are simple work-up,short reaction time, high yields and using eco-friendly metal.

نویسندگان

Samira Jahantigh

Department of Chemistry, Faculty of Science, University of sistan and bluchestan, Zahedan, Iran

Mahboobeh Rezaie Kakhaie

Department of Chemistry, Faculty of Science, University of Sistan and Baluchistan, Zahedan, Iran

Nourrollah Hazeri

Department of Chemistry, Faculty of Science, University of Sistan and Baluchistan, Zahedan, Iran