Overexpression of serum MicroRNA-140-3p in premenopausal women with newly diagnosed breast cancer
محل انتشار: چهاردهمین کنگره بین المللی سرطان پستان
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 463
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شناسه ملی سند علمی:
ICBCMED14_004
تاریخ نمایه سازی: 21 مرداد 1398
چکیده مقاله:
Introduction &Aims: The purpose of the present study was to evaluate microRNA-140-3p expression level in breast cancer patients in comparison to healthy controls.Methods: Serum microRNA-140-3p level was quantified by real-time quantitative reverse transcription PCR in 40 women with breast cancer and 40 healthy subjects.Results: Serum microRNA-140-3p level in patients compared to healthy subjects was significantly up-regulated (p=0.01). MicroRNA-140-3p had a good diagnostic accuracy for discrimination of the two groups (AUC=0.667; sensitivity=70%; specificity=50%). Serum microRNA-140-3p level was overexpressed in premenopausal patients who were ≤48 years old. ROC curve showed a similar pattern again (AUC=0.690; sensitivity=73%; specificity=50%). Conclusions: microRNA-140-3p has the potential for detection of breast cancer, especially in premenopausal (≤48years old) women.
کلیدواژه ها:
نویسندگان
Nadia Heydari
Student Research Committee, Babol University of Medical Sciences, Babol, Iran,
Novin Nikbakhsh
Cancer Research Center, Babol University of Medical Sciences, Babol, Iran,
Farzin Sadeghi
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran,
Nazila Farnoush
Department of Surgery, Babol University of Medical Sciences, Babol, Iran,