Effect of progesterone level in ART

Progesterone level in late follicular phase: Studiesshow that the actual stimulation protocol in IVF cycleinduces supra physiological estradiol during follicularphase. Despite the administration of analogues GnRHmany researchers have described premature luteinizationabout 5-30% premature luteinization is defined as raise inserum progesterone toward the end of the follicularphase. No clear association between progesteroneelevation with fertilization rate and oocyte quality hasbeen observed. However, progesterone elevation hasnegative impact on endometrial receptivity and embryoimplantation.Progesterone in luteal phase: Pregnancy in FET cycleunder hormonal control (HRT) is highly dependent uponserum progesterone mid luteal (Optimal progesterone of70-99 no 1/l). Other studies show that progesterone levelin day of FET does not influence on implanation. Lutealphase serum progesterone level in frsh embryo transfer isa major prerequisite for successful implantation.progesterone level is a promising diagnostic andprognostic parameter for prediction of pregnancy in ICSIETcycles.