Effects of L-Carnitine Supplementation on Insulin Resistance among Pemphigus Vulgaris Patients under Corticosteroids therapy: A Randomized Double-Blind Controlled Trial

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 473

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شناسه ملی سند علمی:

FDSMED07_024

تاریخ نمایه سازی: 17 مرداد 1398

چکیده مقاله:

Background: Pemphigus Vulgaris (PV) is an autoimmune blistering mucocutaneous disorder. Common treatments include corticosteroids drugs. This study aimed to investigate the effect of L-carnitine (LC) supplementation on glycemic indices in PV patients under corticosteroid treatment. Methods: Fifty two patients with pemphigus vulgaris were divided randomly into two groups to receive 2000 mg LC or a placebo.These patients were followed-up for an extended 8 weeks. Serum glycemic indices, were evaluated at baseline and end of intervention period.Results: LC intake was non-significant improvement in the serum of glycemic factors (insulin, FBS, HOMA-IR and QUICKI). (P > .05) after the 8-week intervention.Conclusions: These results indicate no significant effect on insulin, FBS, HOMA-IR, QUICK. large-scale studies are needed to confirm the potential clinical benefits of LC in patients with PV.

نویسندگان

Farnaz Sepandar

Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

Maryam Daneshpazhooh

Autoimmune Bullous Diseases Research Center, Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran

Mahmoud Djalali

Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

Hamed Mohammadi

Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran