Self-assembling peptide nanofibers in tissue engineering

Self-assembling peptide nanofibers has been developed as an emerging 3D scaffold in tissue engineering. These scaffolds may include a self-assembling core and a biological motif. The type of cores and biological motifs influence different biological responses. One of the remarkable advantages of the self-assembling peptide nanofibers is the ability to convert from sol to gel and completely fill the cavities. They are integrated with the edges of the scar without un-wanted immunologic and inflammatory responses of the site of injury. However, it has been disclosed that when biological motifs physically entrapped in scaffolds, induce pronounced biological activity than in soluble form. These scaffolds not only due to chemical composition, but also using nanostructured topography trigger a signal transduction in cells by up-regulation of cell surface receptors such as integrins. Besides, mechanotransuction signals derived from scaffolds at different concentrations will play as a cue in tissue engineering. It is worth noting that there are some clinical trial studies on self-assembling peptide nanofibers, however, some of them has been released in market as a hemostat and dental repair and it seems, they will be promising in tissue engineering

کلیدواژه ها:

Self-assembling peptide ، Nanofibers ، Tissue engineering