Cell-based therapy in spinal muscular atrophy, a review article

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 337

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ITERMED01_354

تاریخ نمایه سازی: 7 مرداد 1398

چکیده مقاله:

IntroductionSpinal muscular atrophy (SMA) is a severe autosomal recessive neuromuscular disease in spinal cord, resulting in progressive proximal muscle weakness and paralysis. Until recently treatment was focused on symptoms, preventing complications, and improving quality of life. Objectives In order to review the latest findings in the field of cell therapyto improve SMA patients. Methods We searched suitable keywords in common medical databases. English articles which published from 1990 extracted and evaluated. ResultsMotor neuron replacement is the ultimate goal in transplantation therapy. Primary Motor neurons (MNs) can be isolate from fresh human or rodent fetal tissue. More promising approaches are the differentiation of embryonic, induced pluripotent stem cells (iPSCs), or fetal-derived neural stem cells (NSCs) into MNs for transplantation. Different neural tissues such as Astrocytes, Human NSCs and Progenitor Cells and iPSCs represent a more natural source for transplantation. Also motor neuron protection with Microglia and Hematopoietic-Derived Stem Cells, Mesenchymal Stem cells become particularly appealing approaches. Combining stem cell transplantation and ex vivo gene therapy or using stem as a vehicle for the delivery of therapeutic compounds such as growth factors is a compelling approach. ConclusionTo date, multiple Non-Neural, neural and stem cell types and methods of administration have been investigated. Optimization of the transplantation techniques, combined with grafting of appropriate cell type expressing, the most potent neuroprotective molecules will undoubtedly lead to the generation of successful therapeutic strategies for treating or preventing motor neuron disorders

نویسندگان

Jafar Ai

Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran university of Medical Sciences, Tehran, iran

Somayeh Ebrahimi-Barough

Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran university of Medical Sciences, Tehran, iran

Reyhaneh Abolghesemi

Nano biotechnology Research Center, Research Center, Center Baqiyatallah University of Medical sciences, Tehran Iran