Renoprotective Effect of Ginger against Nephrotoxicity and Oxidative Stress Induced by Ethanol
محل انتشار: دومین کنفرانس بین المللی فناوری های نوین در علوم
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 340
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شناسه ملی سند علمی:
CMTS02_037
تاریخ نمایه سازی: 29 تیر 1398
چکیده مقاله:
Oxidative damage is one of the most important reasons for chronic renal failure and ginger improves the conditions. In the present study the protective effects of ginger on oxidative stress induced by ethanol in rat kidney were studied. Twenty four adult male Sprague-Dawley rats were randomly allocated into four groups and were treated daily for 28 days as follows: group I: control, group II: ginger (1g/kg/day ginger extract by oral gavage), group III: ethanol (4g/kg/day ethanol by oral gavage) and group IV: ginger+ethanol. At the end of experimental period, tissue sera were used for estimating parameters evaluated. In ethanol group, it was observed significant changes in indices of oxidative stress compared to other groups (P<0.05). The indices of oxidative stress with pretreatment with ginger ameliorated significantly in ginger+ethanol group (P<0.05). It can be concluded that ginger extract has the protective effects against renotoxicity induced by ethanol in the male rat. The protective effect may be due to the presence of phytochemical components and other features that are unknown.
کلیدواژه ها:
نویسندگان
Abolfazl Akbari
Department of Physiology
Khadijeh Nasiri
Biochemistry, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
Mojtaba Heydari
Department of Exercise Physiology, Faculty of Sport Science, University of Mazandaran, Babolsar, Iran
Marjan Chardahcherik
Research Centre for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran