Mohammad Hadi Sadeghian - Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Zahra Rezaei Dezaki - Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Seyyede Fatemeh Shams - Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Sepideh Shakeri - Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: Plasma cell myeloma is the distortion of differentiated B lymphocytes which is associated with uncontrolled proliferation of plasma cells in bone marrow. Some studies propound a role for HHV-8 virus in pathogenesis of plasma cell myeloma. Yet the findings are inconsistent. In this article we reviewed the literatures to determine the HHV-8 virus role in plasma cell myeloma pathogenesis.Methods: In this systematic review, scientific databanks including PubMed, Scopus, Embase, ISI, and Google scholar were searched. The search was based on the subsequent keywords and medical terms in title; different combinations of keywords were used, they were compatible with MeSH terms.Result: Four articles declared that there is no link between the HHV-8 and the pathogenesis of plasma cell myeloma; while five reported a connection between the virus and myeloma, arguing that virus infection will lead to disease progression.Conclusion: There are differences between the results of the studies. It is required to do further researches about the association of HHV-8 and plasma cell myeloma.

Etiology, Human herpes virus 8, Multiple Myeloma