Correlation between Human Herpes virus 8 (HHV8-) and Plasma Cell Myeloma: a Systematic Review

  • سال انتشار: 1397
  • محل انتشار: مجله پزشکی بالینی، دوره: 5، شماره: 3
  • کد COI اختصاصی: JR_RCM-5-3_002
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 378
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نویسندگان

Mohammad Hadi Sadeghian

Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Zahra Rezaei Dezaki

Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Seyyede Fatemeh Shams

Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Sepideh Shakeri

Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

چکیده

Introduction: Plasma cell myeloma is the distortion of differentiated B lymphocytes which is associated with uncontrolled proliferation of plasma cells in bone marrow. Some studies propound a role for HHV-8 virus in pathogenesis of plasma cell myeloma. Yet the findings are inconsistent. In this article we reviewed the literatures to determine the HHV-8 virus role in plasma cell myeloma pathogenesis.Methods: In this systematic review, scientific databanks including PubMed, Scopus, Embase, ISI, and Google scholar were searched. The search was based on the subsequent keywords and medical terms in title; different combinations of keywords were used, they were compatible with MeSH terms.Result: Four articles declared that there is no link between the HHV-8 and the pathogenesis of plasma cell myeloma; while five reported a connection between the virus and myeloma, arguing that virus infection will lead to disease progression.Conclusion: There are differences between the results of the studies. It is required to do further researches about the association of HHV-8 and plasma cell myeloma.

کلیدواژه ها

Etiology, Human herpes virus 8, Multiple Myeloma

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