Antibacterial properties of hydrogel based on chitosan and carboxyl methyl cellulose loaded with antibiotics decorated nanostructures

Burn is one of the damages that a person loses his skin, the first defensive barrier. Since burn wounds are susceptible to various types of infections, choosing the appropriate dressing is very important. Traditional dressings, such as gauze, create a dry and adhesive environment, which cause the wound necrotic. Therefore, it is necessary to develop a dressing with more effective properties in wound healing. An ideal wound dressing not only relieves pain by cooling wound, angiogenesis, tissue remodeling but also prevents the growth of bacteria. The main purpose of this research is to make a hydrogel dressing containing antibacterial agents that keeps the wound moist while absorbs extensive exudate.Natural polysaccharides chitosan has been used owning to hemostatic, bacteriostatic and fungistatic properties. To prepare the composite hydrogel, dialdehyde carboxymethylcellulose (DCMC) can be used as an ideal crosslinker. DCMC improves mechanical properties and enzymatic stability of hydrogel. To generate antibacterial properties, copper oxide nanoparticles were used which can easily combine with polymers or macromolecules. In order to increase antibacterial features, antibiotic- effective on special infection-is loaded on the CuO nanoparticles. Afterwards, Anti/CuO NP anchor on graphene oxide (Anti/CuO NP/ GO) was prepared. Finally, Anti/CuO NP/GO is loaded on chitosan-carboxymethylcellulose hydrogel.The results of this study will be reported completely after laboratory and animal assay.