The Therapeutic Effect of Zinc Sulfate on Neonatal Hyperbilirubinemia

  • سال انتشار: 1396
  • محل انتشار: مجله علمی ناباروری ایران، دوره: 8، شماره: 2
  • کد COI اختصاصی: JR_IRJN-8-2_003
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 515
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نویسندگان

Somayyeh Hashemian

Department of Pediatric Endocrinology and Metabolism .Imam Reza Hospital , Faculty of Medicine, Mashhad University of Medical Sciences , Mashhad, Iran

Ashraf Mohammadzadeh

Neonatal Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Ahmadshah Farhat

Neonatal Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammad Ramezani

Pharmaceutical and Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

چکیده

Background: Approximately 60% of term neonates and 80% of preterm ones suffer from hyperbilirubinemia in theirfirst week of life. This study sought to characterize the therapeutic effect of oral zinc sulfate on neonatalhyperbilirubinemia.Methods: In this randomized, double-blind, placebo-controlled clinical trial, 70 term neonates with total serumbilirubin (TSB) level ≥ 20 mg/dl were enrolled. Thirty-four cases were treated with phototherapy and zinc (10 mg/day,single dose) as case, while the remainder received phototherapy plus placebo. TSB level was measured at the onset ofthe intervention, as well as 12, 24 and 48 h after the intervention and compared with each other.Results: The mean TSB levels were significantly lower in the zinc group after 12, 24 and 48 h (P=0.038, 0.005, 0.001,respectively). The mean durations of phototherapy in the case and control groups were 2.03±0.174 and 2.33±0.478days, respectively, being significantly less in the case group (P=0.002).Conclusion: This study revealed that oral zinc sulfate at a single dose of 10 mg/day diminished TSB level and durationof phototherapy.

کلیدواژه ها

Hyperbilirubinemia, neonate, Treatment, Zinc sulfate

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