Formulation and Physicochemical Evaluation of Medlar (Mespilus germanica) and Oak (Quercus castaneifolia) Effervescent Tablets

  • سال انتشار: 1397
  • محل انتشار: سومین همایش ملی زیست شناسی دانشگاه پیام نور
  • کد COI اختصاصی: BCPNU03_016
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 600
دانلود فایل این مقاله

نویسندگان

Hamed Fathi

Pharmaceutical Sciences Research Center, Hemoglobinopathy Research Center, Mazandaran University of Medical Sciences, Sari, Iran

Ali Davoodi

Deparment of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

Hossein Bakhshi Jouybari

Deparment of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

Pedram Ebrahimnejad

Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

چکیده

Introduction: Effervescent tablet is a convenient oral dosage form, which has special ingredients. This potency of effervescent tablet helps to delivered drugs, effectively. Medicinal plants have a wide range of usage in the world. Mespilus germanica (Rosaceae) and Quercus castaneifolia (Fagaceae) are important medicinal plants used in several diseases such as diarrhea.Methods: Medlar and oak were harvested and extracted using hydro-acetonic solvent by maceration method. In addition, total phenol and tannin contents were assayed using Folin-Ciocalteu method. Antimicrobial activity of extract was determined using broth dilution test on some intestinal pathogens. Finally, effervescent tablets were prepared using wet granulation method and analyzed.Results: Total phenols and tannins were obtained 0.9 % and 0.1 % respectively. This reduces the amounts of total tannins will disappear with adding antioxidant agents. Tablet hardness, friability and disintegration time were significantly dependent on the amounts of lubricant, acidifying and alkalizing agents.Conclusion: This work investigated the potential of developing Oak and Medlar effervescent tablets to facilitate drug administration and mask drug taste. This formula may be encouraging in improving patient compliance and drug efficiency.

کلیدواژه ها

Effervescent Tablet, Medicinal Plant,Oak, Medlar, Formulation

مقالات مرتبط جدید

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.