Amir Abdolmaleki - Anatomy and Cell Biology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Reza Mastery Farahani - Anatomy and Cell Biology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran- Anatomy and Cell Biology Department, School of Medicine Shahid Beheshti University of Medical Sciences, Tehran, Iran Running title: Morp
Nasrin Ahmadinejad - Advanced Diagnostic and Interventional Radiology Research Center (ADIR)Tehran University of Medical Sciences, Tehran, Iran
Seyyed Hossein Mirjavadi - Advanced Diagnostic and Interventional Radiology Research Center (ADIR)Tehran University of Medical Sciences, Tehran, Iran

Purpose: As the largest fiber tract in brain, corpus callosum (CC) constitutes the major connection between two hemispheres of brain. Several lines of evidence indicated that midsagittal plane of CC is affected in patients suffering from Multiple sclerosis (MS). To find probable morphologic changes in CC segments in MS, magnetic resonance imaging (MRI) was used. Materials and Methods: In this line, we analyzed brain MRI images of 54 MS patients compared to 128 healthy individuals MRI images by PmsDViewer software. Data were analyzed by Student’s t-test statistically.Results: MRI morphometric analysis indicated that the proportion of total area of rostrum and genu to the total area of CC (ARG/ACC ratio) significantly increased in MS patients compared to control subjects, whilst the ratio of area of anterior midbody of CC to the total area for CC (AAMB/ACC ratio) notably decreased in the group suffering from MS. Moreover, obtained data revealed that ratio of area of other segments of CC including posterior part of CC, isthmus and splenium to total area of CC showed no significant changes in comparison with healthy volunteers. Conclusions: These findings suggest that the correlation between abnormalities of anterior portion of CC and MS could be considered as a marker for MS diagnosis.

Multiple sclerosis, magnetic resonance imaging, corpus callosum