Interaction Between La(III), Ce(III) Schiff base complexes with salmon sperm DNA

Metal Schiff base complexes, which are known as drugs in cancer chemotherapy, could inhibit in vitro tumor cell growth and can affect the function of proteins, target nucleic acids,catalyze the formation of ROSs and are able to bind and cleave DNAwhich leads to cell cycle arrest and apoptosis[1]. The synthesis of transition metal complexes of unsymmetrical Schiff bases ligands with nitrogen, oxygen and sulfur atoms is an important area of study with implications in bioinorganic chemistry catalysis and medical chemistry [2]. This type of complexes, show strong intercalation with DNA and good biological activity and have received special attention. [3].In this research work, we prepared the new complexes of La,Ce with NOS schiff base ligand has been prepared and fully characterized . The crystalline form of this complexeswere characterized by spectroscopic methods (FT-IR, UV-Vis, 1H-NMR, and luminescence), elemental analysis, and the cyclic voltammetric methods. The fluorescence properties of the compounds have also been investigated. Their binding properties of La(III) and Ce(III) with salmon sperm DNA were investigated using several methods, and the results showed that the intercalated ligand had an important effect on the binding affinity of the Lanthanum and Cerium complexes with DNA. The interactions of that compound with salmon sperm DNA have been investigated by UV–Vis, fluorescence spectroscopies and gel electrophoresis