Title: Insulin resistance improvement by cinnamon powder in polycystic ovary syndrome: A randomized double-blind placebo controlled clinical trial
- سال انتشار: 1397
- محل انتشار: هفتمین سمینار بین المللی سلامت زنان
- کد COI اختصاصی: WHMED07_131
- زبان مقاله: انگلیسی
- تعداد مشاهده: 414
نویسندگان
Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences,Shiraz, Iran
Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences,Shiraz, Iran
Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Our aim is to assess the effect of cinnamon powder capsules on insulin resistance, anthropometric measurements, glucose and lipid profiles, and androgens of women with polycystic ovarian syndrome (PCOS). Method: Out of 80women that were diagnosed as PCOS by Rotterdam Criteria, 66 were enrolled in thisrandomized double‐blind placebo-‐controlled clinical trial. All of the PCOS women were taking medroxy progesterone acetate 10 mg/day for the last 10 days of their menstrual cycles. The cases were randomly allocated to 2 groups. The women in the first group were treated by cinnamon powder capsules 1.5 g/day in 3 divided doses for 12 weeks and the second group by similar placebo capsules. Anthropometric measurements, fasting blood sugar, fasting insulin, blood glucose 2 hr after taking 75 g oral glucose,HbA1c, testosterone, dehydroepiandrosterone sulphate, homeostatic model assessment for insulin resistance, triglyceride, and cholesterol (low-‐density lipoprotein, high-‐density lipoprotein, and total) before and after the intervention were evaluated and compared as outcome measures Result: Fasting insulin (p = .024) and homeostatic model assessment for insulin resistance (p = .014)were reduced after 12 weeks in the cinnamon group compared with the placebo. There was also a significant decrease in lowdensity lipoprotein in cinnamon group (p = .004) as compared with baseline that caused significant difference with placebo (p = .049). Conclusion: The present results suggest that complementary supplementation of cinnamon significantly reduced fasting insulin and insulin resistance in women with PCOS.کلیدواژه ها
cinnamon, fasting insulin, HOMA-‐IR, insulin resistance, polycystic ovary syndromeمقالات مرتبط جدید
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