Evaluation of the protective and therapeutic effects of Pistacia atlantica gum aqueous extract on cellular and pathological aspects of experimental asthma in Balb/c mice
محل انتشار: مجله گیاهان دارویی ابن سینا، دوره: 9، شماره: 3
سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 480
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شناسه ملی سند علمی:
JR_AJP-9-3_006
تاریخ نمایه سازی: 7 خرداد 1398
چکیده مقاله:
Objective: The purpose of this study was to investigate the protective and therapeutic effects of aqueous extract of P. atlantica gum on an experimental asthma in BALB/c mice. Materials and Methods: Aqueous extract of dried and milled P. atlantica gum was assemble andevaluate by GC-MS. In order to investigate the effect of P. atlantica gum extract on cellular and pathological aspects of asthma, 60 BALB/c mice were divided into six groups as: negative control, asthmatic group, asthmatic group receiving dexamethasone (1mg/kg; intraperitoneal (IP)) and three asthmatic groups receiving different concentrations of the extract (100, 200 and 400 mg/kg, orally) from the beginning of the study and continued for 84 days. The examined parameters included cell population, IgE antibody production, levels of IL-4, IL-5, TGF-β, INF-γ, IL-10, and IL-17 cytokines, and lung tissue damage. Results: Regardless of the dose, aqueous extract of P. atlantica gum, caused significant decrease in the number of BALF eosinophilic cells and levels of anti-ovalbumin IgE, IL-4, IL-5 and IL-17 cytokine levels, as well as pathologic damage of the lung tissue. In addition, the amount of anti-inflammatory IL-10, TGF-β, and INF-γ Th1 cytokines significantly increased in the extract-treated groups compared to the asthmatic and dexamethasone-treated groups. Moreover, IFN-γ/IL-4 ratio significantly increased in a dose-dependent manner compared to the un-treated asthma group. Conclusion: The aqueous extract of P. atlantica gum can be considered as a potent anti-inflammatory and immunomodulatory compound and may be used as a natural compound for treatment of immune system disorders.
کلیدواژه ها:
نویسندگان
Zaynab Shakrami
Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran|Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
hadi Esmaeili Gouvarchin ghaleh
Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
bahman mansouri motlagh
Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Ali Sheikhian
Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences.
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