Pivotal role of vitamin D in regulation of inflammatory diseases including cancer, diabetes and autoimmune disorders / Impact of individual disposition and biological variations
- سال انتشار: 1397
- محل انتشار: سومین کنگره بین المللی پزشکی شخصی ایران
- کد COI اختصاصی: IPMCMED03_123
- زبان مقاله: انگلیسی
- تعداد مشاهده: 421
نویسندگان
PhD, ASCP, D.(ABMLI)
چکیده
Vitamin D deficiency is found among one billion human throughout the word, which is associated with increased risk of number of diseases development, such as osteoporosis in adults, rickets in children , as well as various inflammatory disorders including various autoimmune diseases ( i.e., multiple scleorosis, IBD, diabetes type 1 ( TIDM), diabetes type 2 ( T2DM), ),and infectious , cardio vascular , and neurological diseases ,as well as various cancers ( i.e., prostate, breast , colon, gastric, lung, ovarian, skin, bladder, multiple myeloma ) . With special interest, application of proper vitamin D therapeutic strategy reveal an effective approach for preventive, as well therapeutic challenge for many established diseases linked to vitamin D deficiencies. For this therapeutic approach one is required understanding of specific individual biological and conditional status of the person prior to the initiation of the treat -ment. Genome-wide analyses have redefining the pivotal biological role of vit. D on more sixty different cell types of both arms of innate and adaptive immune system , as well as non-immune cell types. In this connection, one of the most active metabolite of vit D( 1, 25(OH)2D , calcitriol, which bind to vitamin D receptor(VDR) to target more than one thousand human genes to direct divers biological function to maintain homeostasis. For example, studies of hundreds of primary 1,25 ( OH) 2D target genes from immune cells clearly ,have demonstrate , that 1,25(OH)2 play crucial role in of induction of anti bacterial proteins in macrophages and dendritic cells (DC) , in modulation of antigen presenting cells, down regulation of T cell proliferation and phenotypic changes , with over-arching effects being to down-regulate immune cells involve in inflammation and promote immune tolerance . In this connection, further genome wide analyses have highlighted, that cytokines pathways can exert positive and negative influence on intracrine 25 vit D system to either enhance or abrogate response to calcitriol. Of further interest 1,25(OH)2D plays a critical role in recruitment and regulation of nuclear transcription factor VDR and retinoid –X receptor (RXR)complex to binds to vitamin D response element (VDRE) in the promoter region of the target genes to recruits transcriptional coactivators or co-repressors to regulate mRNA expression of the target genes.Collectively , vit. D goes through a series of complex biological pathways within each specific bio system to become function or non functional. An effective metabolism of the vit D is generally, govern by individual’s genetic predisposition of the individual , as well as extrinsic and intrinsic influences. For example , VDR polymorphism (i.e., Taq-I, Basm-I, APa-I, Fok-I, Hom-IR) have shown diverse effect on binding ,anti proliferative and anti inflammatory effect of 1,25(OH)2D3 . Furthermore, Interferon ¥ and interleukin-15 exert a positive effect on induction of CYP27B1 expression, whereas, IL-10 , IFN-Β, IL-4, CYP24A1, Fibroblast growth factor 23 ( FGF23) show a negative effect on induction CYP27B1,also miRNA21 suppress CYP27B1. Of interest, in progressive inflammatory diseases , such as cancer overexpress CYP24A1 to become non- responsive to vit D.کلیدواژه ها
مقالات مرتبط جدید
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.